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heredity affects psychotic risk |
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MedWire News: The onset of psychotic disorders and schizophrenia is strongly affected by hereditary factors, with individuals whose parents are both affected having a particularly high risk for the conditions, say scientists.
The exact etiology of psychotic disorders is not clear, but family, twin, and adoption studies have indicated that genetic factors play a major role in their development. However, it is important that these associations are characterized in detail in order to aid future gene identification studies, say Xinjun Li, from the Karolinska Institute in Huddinge, Sweden, and colleagues.
The researchers examined data from the Multigeneration Register, on which all men and women born in Sweden from 1932 onwards are registered with their parents. They crossing-linked this data with that from the Swedish Hospital Discharge Register for 1987 to 2004.
In all, the team identified 21,199 male cases and 19,029 female cases of psychotic disorders, along with 12,799 paternal and 23,021 maternal cases of psychotic disorders. The average age at diagnosis in parents was 53.8 years and 54.8 years for fathers and mothers, respectively, while that in men was 35.9 years, compared with 38.4 years in women.
The average age at diagnosis for cases who had a parent affected by psychotic disorders was 31.3 years and 34.3 years for male and female cases, respectively. Overall hospitalization rates for psychotic disorders were 37.5 per 100,000 for men and 35.2 per 100,000 for women. These rates rose with increasing age until 30-35 years and then decreased. After 40 years of age, female hospitalization rates tended to be greater than those in males.
http://www.psychiatrysource.com/NewsItem/Hereditary-factors-have-strong-affect-on-schizophr.aspx?l1=3
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Mechka |
1 Year, 2 Weeks, 1 day, 20 hours, 45 minutes ago |
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